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🕒 2 weeks ago

E. coli Transforms Plastic Bottles into Paracetamol in 24 Hours

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Image & Source: theguardian

Researchers at the University of Edinburgh have genetically modified E. coli bacteria to transform polyethylene terephthalate (PET) waste into paracetamol, achieving a 92% yield in under 24 hours. This innovation not only tackles the question 'how is paracetamol made' but also explores 'can bacteria break down plastic,' presenting a dual solution to environmental waste and pharmaceutical production challenges.

Building on the discovery that E. coli can convert PET-derived materials into paracetamol, the team utilized a Lossen rearrangement—a chemical reaction previously unseen in nature—to facilitate this transformation. This process, catalyzed by phosphate within the bacterial cells, underscores the potential of synthetic biology in addressing 'how is paracetamol made' and 'can bacteria break down plastic,' paving the way for sustainable drug manufacturing.

Remarkably, the engineered E. coli achieved a 92% conversion rate of PET waste to paracetamol in under 24 hours, showcasing a rapid and efficient method to repurpose plastic waste into valuable pharmaceuticals.

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